Clinical trial shows promise of stem cells in offering safe, effective relief from arthritic knees

Stem cells collected from the patient’s own bone marrow holds great interest as a potential therapy for osteoarthritis of the knee (KOA) because of their ability to regenerate the damaged cartilage. The results were released today in STEM CELLS Translational Medicine (SCTM). KOA is a common, debilitating disease of the aging population in which the … Read more

Releasing an immune system brake could help patients with rare but fatal brain infection: Small-scale, clinical study offers early hope for developing a treatment

PML lesions in the brain. MRI of a PML patient showing significant lesions in the brain (white signal). Credit: Image courtesy of Daniel S. Reich, M.D., Ph.D., NINDS The anti-cancer drug pembrolizumab has shown promise in slowing or stopping the progression of progressive multifocal leukoencephalopathy (PML), a typically fatal infection of the brain caused by … Read more

Privacy curtains could be reservoir of deadly bacteria: study

Credit: CC0 Public Domain Hard-to-clean privacy curtains in hospitals and nursing homes worldwide may be contaminated with deadly drug-resistant bugs, according to findings to be presented Saturday at an infectious diseases conference. More than a fifth of 1,500 samples taken from six post-acute care nursing facilities in the United States were laced with one or … Read more

ICU patients with non-brain-related injuries may suffer undetected cognitive dysfunction

Credit: CC0 Public Domain A new study led by Western University and Lawson Health Research Institute has found that most patients entering hospital intensive care units (ICU) for non-brain-related injuries or ailments also suffer from some level of related cognitive dysfunction that currently goes undetected in most cases. The findings were published today in the … Read more

US FDA approves Johnson & Johnson’s bladder cancer drug

The U.S. Food and Drug Administration on Friday approved Johnson & Johnson’s treatment for patients with a form of bladder cancer. FILE PHOTO: A Johnson & Johnson building is shown in Irvine, California, U.S., January 24, 2017. REUTERS/Mike Blake REUTERS: The U.S. Food and Drug Administration on Friday approved Johnson & Johnson’s treatment for patients … Read more

Top cancer hospitals’ outcomes may be better than affiliates’

(Reuters Health) – Patients often assume that surgical outcomes at all hospitals in a healthcare network are equally good. But a new study comparing outcomes from top-ranked cancer hospitals to their affiliates finds significant differences when it comes to complex cancer surgeries. Researchers found that the likelihood of surviving a complex cancer surgery was greater … Read more

Single-cell sequencing reveals landscape of immune cell subtypes in lung cancer tumors: Map of myeloid immune cell subpopulations points to new targets for immunotherapy

The recent emergence of immunotherapy has marked a sea change in research and care for many forms of cancer, bringing new hope to patients and families around the world. For those who respond to treatment, the results can be dramatic. Activation of a patient’s immune system against cancer can kill or shrink tumors and, in … Read more

Rare gut condition is more predictable from individual’s genetic makeup, study finds

Hirschsprung disease – a rare condition where the failure of gut nerves to develop before birth leads to impaired bowel contractions that prevent infants from passing stool – is more predictable from an individual's genetic makeup than previously envisioned. This is the finding of a study published online in the April 11 edition of the … Read more

US FDA loosens alcohol restrictions for female libido pill

REUTERS: The U.S. Food and Drug Administration said on Thursday women taking Sprout Pharmaceuticals Inc’s female libido pill, Addyi, need not completely avoid alcohol. The FDA ordered Sprout to make changes to the drug’s label to reflect that patients should stop drinking two hours before taking Addyi at bedtime or to skip the dose that … Read more

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