Gilead teams up with insitro for experimental NASH treatments

REUTERS: Gilead Sciences Inc stated on Tuesday it will partner with independently held insitro to establish treatments for a fatty liver illness called non-alcoholic steatohepatitis (NASH), as the drugmaker attempts to conquer its current obstacle in establishing NASH treatments. Insitro will get an in advance payment of US$15 million with extra near-term payments as much … Read more

The protein p38gamma identified as a new therapeutic target in liver cancer: Scientists have shown for the first time that a protein related to cell stress also regulates cell division

An enzyme involved in cell stress responses could become a new pharmacological target in the treatment of liver cancer, a disease that currently has few available treatment options. The research team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Guadalupe Sabio has discovered that the protein p38?, one of the four types of … Read more

Novo Nordisk and Gilead team up to test fatty liver disease treatment

COPENHAGEN: Novo Nordisk and Gilead Sciences will join forces on a clinical trial combining drugs from the two pharmaceutical firms to treat a progressive fatty liver disease known as NASH. The clinical trial will be a study combining Novo Nordisk’s semaglutide drug and Gilead’s cilofexor and firsocostat for treatment of patients with Nonalcoholic steatohepatitis (NASH), … Read more

The protein p38-gamma identified as a new therapeutic target in liver cancer

Hepatocytes during the cell division process. Credit: CNIC An enzyme involved in cell stress responses could become a new pharmacological target in the treatment of liver cancer, a disease that currently has few available treatment options. The research team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Guadalupe Sabio has discovered that the … Read more

Cellular protein could take on role of restriction factor for hepatitis B virus

Hepatitis B is a viral liver infection that can lead to acute or chronic conditions. Although there is a vaccine that offers protection against the virus, current treatments which prevent the virus from replicating are not curative for infected individuals. Scientists at the Institut Pasteur working in collaboration with the CNRS have demonstrated that a … Read more

A tiny cry for help from inside the liver could lead to better treatment

Depiction of the newly discovered role of the enzyme CPS1 in sounding the alarm about liver damage and bringing in anti-inflammatory immune cells. Credit: University of Michigan On a normal day, the cells of a human liver do what they do best—making key blood proteins, clearing toxins from the blood and sending their remains down … Read more

US liver cancer deaths more common with less education

Liver cancer is the most rapidly rising cause of U.S. cancer deaths, and most of those dying from this disease are people with less education, a new study suggests. During the study – from 2000 to 2015 – liver cancer death rates nationwide rose from 7.5 to 11.2 fatalities for every 100,000 men ages 25 … Read more

Mutations in human livers can promote tissue regeneration

Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified genetic mutations that accumulate in the adult liver that can promote regeneration in the context of chronic liver damage. The widespread use of genome sequencing has led to the realization that normal tissues in healthy people accumulate spontaneous changes in DNA, … Read more

Scientists find new therapy target for drug-induced liver failure

Findings from a new mouse study suggest that treatments that increase levels of the protein thrombospondin-1 could help the liver recover from an overdose of acetaminophen. Credit: Matthew McMillin Acetaminophen—a commonly used pain reliever and fever reducer—is the leading cause of quickly developing, or acute, liver failure in the U.S. Findings from a new mouse … Read more

How Whole Grains Could Help Your Liver

Credit: Shutterstock ATLANTA — Eating whole grains and cereal may reduce the risk of liver cancer. That's according to findings presented Tuesday (April 1) here at the annual meeting of the American Association for Cancer Research (AACR). Eating a diet rich in whole grains and dietary fiber has been linked to numerous health benefits, including … Read more

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