The Quest For the Roots of Autism — and What It Says About Us All

( Credit: Brian Stauffer/brianstauffer. com) As alarm grew over autism occurrence at the turn of this century, there was much public talk of a growing “epidemic.” That language has actually because softened, and it is now clear that numerous autistic individuals existed all along, their condition unacknowledged till fairly just recently. However what is the … Read more

Scientists Discover Genes Causing Age-Related Hearing Loss

Researchers are simply beginning to unwind the hereditary reasons for age-related hearing loss. (Credit: Tish1/Shutterstock) Although our ears grow as we age, our hearing tends to fade. This paradoxical issue prevails and gets gradually even worse the older we get. An approximated 25 percent of Americans in between the ages of 65 and 74 have … Read more

Hundreds of new anti-cancer drug targets identified using CRISPR

A team of scientists from the Wellcome Sanger Institute have identified the genes that are essential for the survival of thirty types of cancer cells. The resultant cancer dependency map will facilitate the development of novel targeted cancer treatments. The study, which is entitled “Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens”, was published in … Read more

Large-scale screen of mouse mutants reveals 38 new genes involved in hearing loss

A large-scale screen of mouse mutants has revealed multiple new genes involved in hearing loss, according to a study publishing April 11 in the open-access journal PLOS Biology by Karen Steel of King’s College London and the Wellcome Sanger Institute, and colleagues. The new genes identified reveal metabolic pathways and regulatory processes involved in hearing … Read more

Cancer-killing combination therapies unveiled with new drug-screening tool: Method IDs which targeted therapies, inadequate on their own, can be paired up to kill non-responsive cancers

UC San Francisco scientists have designed a large-scale screen that efficiently identifies drugs that are potent cancer-killers when combined, but only weakly effective when used alone. Using this technique, the researchers eradicated a devastating blood cancer and certain solid tumor cells by jointly administering drugs that are only partially effective when used as single-agent therapies. … Read more

Mice reveal 38 new genes involved in hearing loss

Organ of Corti whole-mount image, with sensory hair cells labelled with Myo7a antibody (red) showing 3 rows of outer hair cells (top) and one row of inner hair cells (bottom). Nuclei labelled with DAPI (blue). Credit: Elisa Martelletti Multiple new genes involved in hearing loss have been revealed in a large study of mouse mutants … Read more

Bacteria share genes with one another, even across tissue boundaries

Bacteria in the human body are sharing genes with one another at a higher rate than is typically seen in nature, and some of those genes appear to be traveling – independent of their microbial hosts – from one part of the body to another, researchers report in the journal Scientific Reports. The findings are … Read more

Rare gut condition is more predictable from individual’s genetic makeup, study finds

Hirschsprung disease – a rare condition where the failure of gut nerves to develop before birth leads to impaired bowel contractions that prevent infants from passing stool – is more predictable from an individual's genetic makeup than previously envisioned. This is the finding of a study published online in the April 11 edition of the … Read more

Cancer: Scientists find 129 ‘jumping genes’ that drive tumor growth

In cancer research, scientists usually look for cancer genes by scouring the genome for altered sequences — or mutations — in DNA. But a new study has now revealed that jumping genes, which customary sequencing overlooks, are also important drivers of tumor growth.Researchers have uncovered 129 jumping genes that may drive cancer. Scientists at the … Read more

New cancer drug targets accelerate path to precision medicine

Credit: CC0 Public Domain In one of the largest studies of its kind, researchers used CRISPR technology to disrupt every gene in over 300 cancer models from 30 cancer types and discover thousands of key genes essential for cancer’s survival. The team, from the Wellcome Sanger Institute and Open Targets, then developed a new system … Read more

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