This drug failed to treat cancer, but it could improve dementia

Dementia — an umbrella term for various neurodegenerative conditions involving memory loss and other forms of cognitive impairment — is hard to treat because its causes remain unknown. Researchers, however, are making painstaking progress. A new approach to dementia research may bring us closer to a treatment, but unexpected challenges could halt this progress. Dr. … Read more

US FDA approves Johnson & Johnson’s bladder cancer drug

The U.S. Food and Drug Administration on Friday approved Johnson & Johnson’s treatment for patients with a form of bladder cancer. FILE PHOTO: A Johnson & Johnson building is shown in Irvine, California, U.S., January 24, 2017. REUTERS/Mike Blake REUTERS: The U.S. Food and Drug Administration on Friday approved Johnson & Johnson’s treatment for patients … Read more

Clovis Oncology halts mid-stage bladder cancer trial, shares drop

REUTERS: Clovis Oncology Inc said on Friday (Apr 12) it was halting a mid-stage trial testing its lead drug in bladder cancer patients, sending shares down 12 per cent. The company said its decision to discontinue the trial was based on recommendations of an independent committee, which suggested that the treatment may not provide a … Read more

Experimental drug delivers one-two punch to vision loss: Experiments show new therapy slows blood vessel leakage associated with diabetic macular edema and macular degeneration

Images of the mouse retina with a fluorescent fluid tracer. Diseased blood vessels allow the tracer to permeate nearby tissues. Vessels treated with AXT107 do not allow fluids to escape and exhibit clean crisp borders with surrounding tissue. Credit: Alexsander Popel In studies with lab-grown human cells and in mice, Johns Hopkins Medicine researchers have … Read more

US FDA loosens alcohol restrictions for female libido pill

REUTERS: The U.S. Food and Drug Administration said on Thursday women taking Sprout Pharmaceuticals Inc’s female libido pill, Addyi, need not completely avoid alcohol. The FDA ordered Sprout to make changes to the drug’s label to reflect that patients should stop drinking two hours before taking Addyi at bedtime or to skip the dose that … Read more

Underwater forests a treasure trove of new drugs: Scientists recover dozens of antimicrobial and anticancer compounds from seaweed

Defensive compounds produced by microbes are a major source of antibiotics and other important medicines. But with resistant bugs appearing faster than potential allies, researchers are taking their search for drug candidates offshore. Published in Frontiers in Microbiology, a new study reveals for the first time that a common species of seaweed, Laminaria ochroleuca, is … Read more

Active lifestyles may help nerves to heal after spinal injuries

A dorsal root ganglion neuron treated with the CBP-activator drug CSP-TTK21. Red – neuronal marker (Beta-III-tubulin) and green – H4K8 acetylation. Credit: Simone Di Giovanni and Thomas Hutson / Imperial College London Leading an active lifestyle may increase the likelihood of damaged nerves regenerating after a spinal cord injury. The early-stage findings, published in the … Read more

New cancer drug targets accelerate path to precision medicine

Credit: CC0 Public Domain In one of the largest studies of its kind, researchers used CRISPR technology to disrupt every gene in over 300 cancer models from 30 cancer types and discover thousands of key genes essential for cancer’s survival. The team, from the Wellcome Sanger Institute and Open Targets, then developed a new system … Read more

Alcohol, Cannabis and Other Drugs: A Pharmacological Evaluation

The abuse of alcohol and other drugs like narcotics, sedatives and stimulants continues to be a major global public health concern. This international crisis is further heightened by the tendency of many users to poly-drug abuse, which is a condition defined as the simultaneous or successive abuse of more than one drug or type of … Read more

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