Dutch doctor ‘fathered 49 children’ in IVF scandal

The Dutch physician, now deceased, apparently utilized his own sperm rather of those from a donor to inseminate clients AFP/LLUIS GENE. THE HAGUE: A departed Dutch physician bogged down in a fertility scandal fathered a minimum of 49 kids, an organisation representing moms and dads and kids born through IVF at his now-closed center stated … Read more

DNA fragments from ancient hominins reveal new branches of the Denisovan lineage

It's widely accepted that anatomically modern humans interbred with their close relatives, the Neanderthals and Denisovans, as they dispersed out of Africa. But a study examining DNA fragments passed down from these ancient hominins to modern people living in Island Southeast Asia and New Guinea now suggests that the ancestry of Papuans includes not just … Read more

‘Three-person’ baby born in medical ‘revolution’ in Greece

File photo of in-vitro fertilisation, in which eggs were harvested from a woman’s ovaries, fertilised, and then cryogenically preserved. (Photo: AFP) ATHENS: A team of Greek and Spanish doctors announced Thursday (Apr 11) the birth of a baby using DNA from three people after a controversial fertility treatment that has provoked intense ethical debate. The team … Read more

Three-person baby born in medical ‘revolution’

Credit: CC0 Public Domain A team of Greek and Spanish doctors announced Thursday the birth of a baby using DNA from three people after a controversial fertility treatment that has provoked intense ethical debate. The team used an egg from the infertile mother, the father’s sperm and another woman’s egg to conceive the baby boy, … Read more

New strategy for editing and repairing genetic mutation associated with microduplications

Scientists at UMass Medical School have developed a strategy for editing and repairing a particular type of genetic mutation associated with microduplications using CRISPR/Cas9 and a seldom-used DNA repair pathway. Described in Nature, this approach to programmable gene editing overcomes prior inefficiencies in gene correction. "It's like hitting the reset button," said Scot A. Wolfe, … Read more

Cancer: Scientists find 129 ‘jumping genes’ that drive tumor growth

In cancer research, scientists usually look for cancer genes by scouring the genome for altered sequences — or mutations — in DNA. But a new study has now revealed that jumping genes, which customary sequencing overlooks, are also important drivers of tumor growth.Researchers have uncovered 129 jumping genes that may drive cancer. Scientists at the … Read more

Mapping cellular diversity by looking for common topics of gene control

A Belgian team of computational biologists led by Stein Aerts (VIB-KU Leuven) has developed a new bioinformatics method called cisTopic. Inspired by text-mining methods, cisTopic helps scientists to gain insight into the mechanisms underlying the differences in gene regulation across and within the cells in our body by looking for common topics. In a new … Read more

Unjamming the genome after DNA damage: A gene regulatory multi-tool has yet another function

Ccr4-Not to the rescue. A) Ccr4-Not complex associates with RNA polymerase II (RNAPII) as it travels along a strand of DNA producing RNA. B) When RNAPII becomes stuck due to DNA damage, Ccr4-Not recruits factors that mark RNAPII with a small signaling molecule called ubiquitin. C) Ubiquitylation triggers degradation of RNAPII, allowing DNA repair enzymes … Read more

A gene regulatory multi-tool plays key role in unjamming the genome after DNA damage

A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA. RNA polymerase II (RNAPII)–the enzyme that produces RNA from a DNA template–can become stuck due to … Read more

Harvard doc says neonatal DNA tests could save young lives

DNA testing could save young lives through early intervention Pediatric oncologist Lisa Diller is studying the implications of genetic testing in newborns. Jon Chase/Harvard Staff Photographer Radcliffe researcher explores genetic testing in newborns that could help them escape severe health consequences A few months ago, Lisa Diller saw a family for a consultation in her … Read more

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