Cancer: Novel cell death technique may be better than chemo

Chemotherapy, radiotherapy, and immunotherapy are typically used to treat cancer, but they do not work for all patients with the disease. In a new study, scientists have discovered a cancer-killing technique that might be more effective than conventional cancer therapies.Researchers have discovered a potentially more effective way to kill cancer cells. Researchers reveal how a … Read more

Study describes vulnerability shared by large subset of cancer cell lines

Cancer cells adapt to potentially fatal mutations and other molecular malfunctions by adjusting one or more other genes' activity, in the process becoming dependent on those genes for their survival and growth. The resulting genetic dependencies may provide targets for developing new precision-guided drugs or other cancer treatment strategies. Reporting in Nature, researchers led by … Read more

The protein p38gamma identified as a new therapeutic target in liver cancer: Scientists have shown for the first time that a protein related to cell stress also regulates cell division

An enzyme involved in cell stress responses could become a new pharmacological target in the treatment of liver cancer, a disease that currently has few available treatment options. The research team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Guadalupe Sabio has discovered that the protein p38?, one of the four types of … Read more

AMSBIO announces new concept to culture cells without using serum

AMSBIO announces XerumFree™ – a new concept in cell culture that allows you to culture cells without the use of serum. XerumFree™ has been developed taking into account what is missing in traditional basal cell culture media to sustain growth of all cell types, which is a nutritional approach at the cellular level. Containing no … Read more

Single-cell sequencing reveals landscape of immune cell subtypes in lung cancer tumors: Map of myeloid immune cell subpopulations points to new targets for immunotherapy

The recent emergence of immunotherapy has marked a sea change in research and care for many forms of cancer, bringing new hope to patients and families around the world. For those who respond to treatment, the results can be dramatic. Activation of a patient’s immune system against cancer can kill or shrink tumors and, in … Read more

Progress toward Epstein-Barr virus vaccine

This is a cryo-EM image of the gH/gL/gp45 candidate vaccine construct. Credit: NIAID A research team led by scientists from NIH’s National Institute of Allergy and Infectious Diseases (NIAID) has determined how several antibodies induced by Epstein-Barr virus (EBV), a herpesvirus that causes infectious mononucleosis and is associated with certain cancers, block infection of cells … Read more

Mapping cellular diversity by looking for common topics of gene control

A Belgian team of computational biologists led by Stein Aerts (VIB-KU Leuven) has developed a new bioinformatics method called cisTopic. Inspired by text-mining methods, cisTopic helps scientists to gain insight into the mechanisms underlying the differences in gene regulation across and within the cells in our body by looking for common topics. In a new … Read more

Cancer: ‘Off-the-shelf’ stem cell treatment enters clinical trial

In a first-of-its-kind trial in the United States, researchers are testing a stem cell-derived natural killer cell immunotherapy in people with incurable cancer. Natural killer cells can detect and destroy cancer cells. Cancer follows heart disease as the second biggest killer worldwide. In the United States, an estimated 606,880 people will die due to cancer … Read more

The protein p38-gamma identified as a new therapeutic target in liver cancer

Hepatocytes during the cell division process. Credit: CNIC An enzyme involved in cell stress responses could become a new pharmacological target in the treatment of liver cancer, a disease that currently has few available treatment options. The research team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Guadalupe Sabio has discovered that the … Read more

Researchers develop new method for identifying compounds that prevent aging

Researchers at Karolinska Institutet in Sweden have developed a new method for identifying compounds that prevent aging. The method is based on a new way of determining age in cultured human cells and is reported in a study in the journal Cell Reports. Using the method, the researchers found a group of candidate substances that … Read more

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