Research team identifies potential drug to treat SARS-CoV-2

Novel Coronavirus SARS-CoV-2 Transmission electron micrograph of SARS-CoV-2 virus particles, remoted from a affected person. Picture captured and color-enhanced on the NIAID Built-in Analysis Facility (IRF) in Fort Detrick, Maryland. Credit score: Nationwide Institute of Allergy and Infectious Ailments, NIH

A federally permitted coronary heart medicine reveals important effectiveness in interfering with SARS-CoV-2 entry into the human cell host, in accordance with a brand new research by a analysis workforce from Texas A&M College and The College of Texas Medical Department (UTMB).

The medicine bepridil, which matches by the commerce identify Vascor, is at present permitted by the U.S. Meals and Drug Administration (FDA) to deal with angina, a coronary heart situation.

The workforce’s leaders are Faculty of Science professor Wenshe Ray Liu, professor and holder of the Gradipore Chair within the Division of Chemistry at Texas A&M, and Chien-Te Kent Tseng, professor and director of the SARS/MERS/COVID-19 Laboratory at UTMB. Liu additionally holds joint school positions in Texas A&M’s schools of medication and agriculture and life sciences.

“Just one medicine is at present obtainable, Remdesivir, to offer restricted advantages to COVID-19 sufferers, and the virus could simply evade it,” Liu mentioned. “Discovering different medicines is crucial. Our workforce screened greater than 30 FDA/European Medicines Company permitted medicine for his or her potential to inhibit SARS-COV-2’s entry into human cells. The research discovered bepridil to supply essentially the most potential for remedy of COVID-19. Consequently, we’re advocating for the intense consideration of utilizing bepridil in scientific exams associated to SARS-CoV-2.”

The Texas A&M-UTMB research is now obtainable on the web site of the peer-reviewed Proceedings of the Nationwide Academy of Sciences (PNAS) and is scheduled for print publication on March 9.

The workforce, which incorporates six different researchers from Texas A&M and 4 from UTMB, now plans to advance their work to animal fashions with a possible for scientific trials.

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